Synthesis of homochiral dihydroxy-4-nitroisoxazolines via one-pot asymmetric dihydroxylation-reduction |
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| Authors: | Adamo Mauro F A Nagabelli Murali |
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| Institution: | Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medical Chemistry, The Royal College of Surgeons in Ireland, Dublin, Ireland. madamo@rcsi.ie |
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| Abstract: | Herein we report a one-pot procedure to prepare a family of homochiral dihydroxy-4-nitroisoxazolines 3. This new methodology affords the title compounds in good yields, excellent enantiopurity, and without the use of chromatography. |
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