Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions |
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| Authors: | Clarisse Damien Pelotier Béatrice Piva Olivier Fache Fabienne |
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| Affiliation: | Université de Lyon, Université Lyon 1, ICBMS, équipe SURCOOF, CNRS, UMR 5246, Bat. Raulin, 43 Bd du 11 Nov. 1918, 69622 Villeurbanne cedex, France. |
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| Abstract: | Prins cyclization between a homoallylic alcohol and an aldehyde, promoted by trimethylsilyl halide, afforded 4-halo-tetrahydropyrans with good to excellent yields. Thanks to the absence of the solvent and metal, the THP thus obtained have been implicated without purification in several other reactions, in a sequential way, affording in particular new indole derivatives. |
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