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Combined ligand-based and structure-based design of PDE 9A inhibitors against Alzheimer’s disease |
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| Authors: | Swetha Rayala Sharma Anjali Singh Ravi Ganeshpurkar Ankit Kumar Devendra Kumar Ashok Singh Sushil K |
| Institution: | 1.Pharmaceutical Chemistry Research Laboratory 1, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India ;2.Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharti Vidyapeeth University, Pune, India ;3.Faculty of Pharmacy, DIT University, Uttarakhand, India ; |
| Abstract: | Molecular Diversity - PDE9 enzyme hydrolyzes cGMP, which is involved in the regulation of synaptic plasticity through the NMDA pathway (a well-known excitotoxic target for AD) via activation of... |
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