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Bioelectrochemistry for sensing amino acids,peptides, proteins and DNA interactions
Authors:Ana Maria Oliveira-Brett  Victor Constatin Diculescu  Teodor Adrian Enache  Isabel PG Fernandes  Ana-Maria Chiorcea-Paquim  S Carlos B Oliveira
Institution:Department of Chemistry, Faculty of Sciences and Technology, University of Coimbra, 3004-535 Coimbra, Portugal
Abstract:Oxidative damage to peptides, proteins and DNA is considered to be one of the major causes of cancer and age-related diseases. The interaction of biomolecules, peptides, proteins, nucleic acids and pharmaceuticals with solid electrode surfaces is not only a fundamental phenomenon but also a key to important and novel analytical sensing applications in biosensors, biotechnology, medical devices and drug-delivery schemes. Electrochemical methods can provide insight into the redox mechanisms and the electron-transfer reactions of a variety of fundamental biological processes.
Keywords:Oxidative damage  Peptides  Proteins  DNA  Electrochemistry
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