Signal enhancement of electrochemical DNA biosensors for the detection of trace heavy metals |
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Authors: | Jiadi Sun Ying Gan Tao Liang Shuqi Zhou Xinyi Wang Hao Wan Ping Wang |
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Affiliation: | 1. Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China;2. State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai, 200050, China |
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Abstract: | Heavy-metal pollution has attracted intensive attention from the public because of the severe threats of heavy metals to the ecosystem and human health. Ultralow concentration of heavy metals in aquatic environment leads to the urgent needs of sensitive approaches for heavy-metal detection. Electrochemical DNA biosensors present outstanding superiority in convenience, selectivity, and sensitivity compared with conventional methods. To achieve the ultralow detection limit, efforts have been made to implement signal enhancement strategies to develop electrochemical DNA biosensors with enhanced sensing performance. This review focuses on the recent progress in signal enhancement strategies applied to electrochemical DNA biosensors for heavy-metal-ion detection including nicking enzyme–assisted amplification, the utilization of core–shell nanoparticles, and nanocomposites modification. |
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Keywords: | Signal enhancement Electrochemical DNA biosensor Heavy metal ions |
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