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Nanoelectrochemical analysis inside a single living cell
Authors:Xinwei Zhang  Amir Hatamie  Andrew G. Ewing
Affiliation:Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
Abstract:This critical opinion reviews the methods to construct and apply electrodes for analysis inside single cells and of single organelles. Nanoelectrochemical methodology, with an emphasis on nanoelectrode construction and analysis of metabolites, neurotransmitters, reactive oxygen and nitrogen species, glucose, oxygen, hydrogen peroxide, and ions in cells are discussed for measurements from cytoplasm to single organelles.
Keywords:Nano-electrodes  Intracellular  Vesicle  Phagolysosome  Neurotransmitter  Reactive oxygen species
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