| Synthesis and Characterization of a Novel Galactosylated Cholesterol |
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| 引用本文： | Shao Ning WANG Ying Kun QIU Hui XU Yi Hui DENG Da Wei CHEN. Synthesis and Characterization of a Novel Galactosylated Cholesterol[J]. 中国化学快报, 2006, 17(2): 173-176 |
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| 作者姓名： | Shao Ning WANG Ying Kun QIU Hui XU Yi Hui DENG Da Wei CHEN |
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| 作者单位： | Shao Ning WANG1，Ying Kun QIU2，3，Hui XU1，Yi Hui DENG1，Da Wei CHEN1 1School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016 2School of Pharmcy，Yantai University，Yantai 264005 3Shandong Engineering Research Center of Natural Drugs，Yantai 264003 |
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| 摘 要： | Mammalian hepatocytes (parenchymal cells) exclusively possess large number ofasialoglycoprotein receptors (ASGPr), which can recognize terminal D-galactose orN-acetylgalactosamine residues. Lactobionic acid 1, bearing a galactosyl group, isusually used as…
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| 关 键 词： | 合成 表征 半乳糖苷胆固醇 肝细胞选择性 亚德里亚霉素 抗肿瘤药物 |
| 收稿时间： | 2005-06-02 |
Synthesis and Characterization of a Novel Galactosylated Cholesterol |
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| Shao Ning WANG,Ying Kun QIU,Hui XU,Yi Hui DENG,Da Wei CHEN. Synthesis and Characterization of a Novel Galactosylated Cholesterol[J]. Chinese Chemical Letters, 2006, 17(2): 173-176 |
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| Authors: | Shao Ning WANG Ying Kun QIU Hui XU Yi Hui DENG Da Wei CHEN |
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| Abstract: | A novel galactosylated cholesterol with mono-galactoside moiety, (5-cholesten-3-yl)-4-oxo-4-[2-(lactobionylamido)ethylamido]butanoate 6 was synthesized. Its chemical structurewas characterized by IR, ESI-MS, C NMR, H NMR. Doxorubicin entrapped in the liposomes 13 1containing 10% mol/mol 6 was rapidly accumulated in liver and mainly uptake by parenchymalcells in mice. |
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| Keywords: | Galactosylated cholesterol (5-cholesten-3-yl)-4-oxo-4-[2-(lactobionylamido)ethyl-amido]butanoate hepatocyte-selective targeting doxorubicin. |
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