| 4-羟基-2-吡啶酮类天然生物碱的研究进展 |
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| 引用本文： | 唐玉敏,李晶,赵圣印. 4-羟基-2-吡啶酮类天然生物碱的研究进展[J]. 有机化学, 2011, 31(1): 9-21 |
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| 作者姓名： | 唐玉敏 李晶 赵圣印 |
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| 作者单位： | 东华大学化学化工与生物工程学院,上海,201620 |
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| 基金项目： | 国家自然科学基金(No.21072029); 上海市自然科学基金(No.10ZR1400700); 东华大学中央高校基本科研业务费专项基金(No.2009D-12)资助项目 |
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| 摘 要： | 4-羟基-2-吡啶酮类生物碱是从植物和昆虫等内生真菌发酵液中提取分离得到的一类新型天然生物碱, 具有抗真菌、抗菌和抗肿瘤等多种生物活性. 对近年来4-羟基-2-吡啶酮类天然生物碱的分离、结构确证和全合成等进行了总结和概述, 重点介绍了Ilicilolin H, Tenellin和Sambutaxin等的全合成.
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| 关 键 词： | 4-羟基-2-吡啶酮 生物碱 分离 全合成 |
| 收稿时间： | 2009-12-22 |
| 修稿时间： | 2010-05-31 |
Progress in the Study of 4-Hydroxy-2-pyridone Natural Alkaloids |
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| Tang Yumin,Li Jing,Zhao Shengyin. Progress in the Study of 4-Hydroxy-2-pyridone Natural Alkaloids[J]. Chinese Journal of Organic Chemistry, 2011, 31(1): 9-21 |
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| Authors: | Tang Yumin Li Jing Zhao Shengyin |
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| Affiliation: | (College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620) |
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| Abstract: | 4-Hydroxy-2-pyridones are embedded as common structural units of many natural products. They exhibited good or excellent biological activities such as antifungal, antibacterial, and cytototoxic activity and so on. The class of compounds has stimulated a great deal of interest on synthetic chemists due to their structural novelty, molecular diversity, and promising biological activities. In this article, the recent progress in the isolation, structural elucidation and total synthesis of 4-hydroxy-2-pyridone natural alkaloids have been reviewed, especially on total synthesis of ilicilolin H, tenellin and sambutaxin. |
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| Keywords: | 4-hydroxy-2-pyridone alkaloids isolation total synthesis |
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