Strategies for single particle manipulation using acoustic and flow fields |
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Authors: | S Oberti D Möller J Dual BJ Nelson |
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Institution: | a Institute of Mechanical Systems, Dept. of Mechanical and Process Eng., ETH Zurich, CH-8092 Zurich, Switzerland b Institute of Robotics and Intelligent Systems, ETH Zurich, 8092 Zurich, Switzerland c Dept. of Mechanical and Aerospace Engineering, Monash University, VIC 3800, Australia d Swiss Light Source at Paul Scherrer Institute, CH-5232 Villigen, Switzerland |
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Abstract: | Acoustic radiation forces have often been used for the manipulation of large amounts of micrometer sized suspended particles. The nature of acoustic standing wave fields is such that they are present throughout the whole fluidic volume; this means they are well suited to such operations, with all suspended particles reacting at the same time upon exposure. Here, this simultaneous positioning capability is exploited to pre-align particles along the centerline of channels, so that they can successively be removed by means of an external tool for further analysis. This permits a certain degree of automation in single particle manipulation processes to be achieved as initial identification of particles’ location is no longer necessary, rather predetermined. Two research fields in which applications are found have been identified. First, the manipulation of copolymer beads and cells using a microgripper is presented. Then, sample preparation for crystallographic analysis by positioning crystals into a loop using acoustic manipulation and a laminar flow will be presented. |
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Keywords: | Ultrasound Cell manipulation Particle manipulation Crystal manipulation Single particle manipulation |
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