Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides |
| |
Authors: | Nasser R El-Brollosy |
| |
Institution: | (1) Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv-94, Murmanska str. 5, Kyiv, Ukraine;(2) Department of Chemistry, The University of South Florida, 4202 E. Fowler Avenue, SCA 400, Tampa, Florida 33620, USA;(3) IBCP, CNRS UMR 5086, 7 passage du Vercors, Lyon, F69367, France; |
| |
Abstract: | The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction
of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)-6-azauracils
and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|