Synthesis of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide-O-sulfate: A potential metabolite of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide

The sulfate conjugate 2 of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide, a potential metabolite of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide, is prepared from the 2-hydroxysuccinimide ( 1 ) by the reaction with chlorosulfonic acid in chloroform and ether mixture at ?78°.