Michael addition of benzoylacetonitrile to chiral α-cyanoacrylates derived from enantiomerically pure α-hydroxyaldehydes: Synthesis of 3-alkoxycarbonyl-4-alkyl-2-amino-5-cyano-6-phenyl-4H-pyrans |
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Authors: | Blanca Jim nez,Nazario Martí n,Angeles Martí nez-Grau,Carlos Seoane,Jos L. Marco |
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Affiliation: | Blanca Jiménez,Nazario Martín,Angeles Martínez-Grau,Carlos Seoane,José L. Marco |
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Abstract: | We describe the Michael addition of benzoylacetonitrile to α-cyanoacrylates 4a-c and 5a obtained from readily available chiral α-hydroxyaldehydes 1a-c . The resulting polyfunctionalized 4-alkyl-2-amino-4H-pyrans 6a-c, 7a have been obtained in good yield and moderate diastereoselectivity. |
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