The reformatsky reaction of 1-acyl-3,5-dimethylpyrazoles. A convenient preparation of 4-amino-3-oxoalkanoic acid derivatives

The conversion of N-acylpyrazoles into β-keto esters was accomplished efficiently by the treatment with α-bromo esters and zinc dust. Using this Reformatsky reaction of N-acylpyrazoles, 4-(protected amino)-3-oxoalkanoic acid derivatives were conveniently prepared as the key intermediates in the synthesis of statines.