Synthesis of spiro[4′,5′,10,11-tetrahydro-5H-dibenzo[a,d]cyclohepten-5-yl-2′(3′H)-furans] as potential cytokine inhibitors

A synthesis of novel spiro4′,5′,10,11-tetrahydro-5H-dibenzoa,d]cyclohepten-5-yl-2′(3′H)-furans] is described. The key reaction was formation of the tetrahydrofuran ring by cyclization of the diol 3 or the protected diol 10. These compounds were investigated as potential TNF-α inhibitors.