First Use of Benzyl Phosphites in the Michaelis-Arbuzov Reaction synthesis of mono-, Di-, and triphosphate analogs

Benzyl phosphites were used in the Micaelis-Arbuzov reaction. Special experimental conditions allowed preparation of a set of phosphonate analogs of mono-, di-, and triphosphate. Furthermore, regioselective monodeprotection makes these molecules useful building blocks for the synthesis of analogs of polyphosphorylated compounds of biological interest (e.g. nucleotides), after removal of all phosphonate benzyl ester groups under very mild conditions and high yields.