Long-range fluorine-proton coupling in 1,2,4-triazole derivatives |
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Authors: | John M Kane Christopher R Dalton Michael A Staeger Edward W Huber |
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Abstract: | Several 1,2,4-triazole derivatives containing a 2-fluorophenyl substituent at either the 3- or 5-position and a methyl group at the 4-position were synthesized. These derivatives exhibit long-range 19F-1H and 19F-13C through-space coupling in their 1H and 13C nmr spectra between the fluorine and the 4-methyl group. The close spatial proximity of these nuclei was confirmed by X-ray analysis and by fluorine irradiated proton observe ({19F}-1H) NOE difference spectroscopy. |
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