Saturated heterocycles. Part 216 . Synthesis,structure and ring opening of trans-perhydro-1,4-benzoxazepin-3-one derivatives |
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Authors: | Lajos Simon,S. Gizella Talpas,Ferenc Fü l p,G bor Bern th,Gyula Argay,Alajos K lm n,P L Soh r |
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Affiliation: | Lajos Simon,S. Gizella Talpas,Ferenc Fülöp,Gábor Bernáth,Gyula Argay,Alajos Kálmán,PÁL Sohár |
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Abstract: | trans-Perhydro-1,4-benzoxazepin-3-ones 2a-c were synthesized and transformed to condensed-skeleton perhydro-trans-1,4-benzoxazepines 3a,b , the thiones 4a,b , the urea derivatives 5a,b , and N-acylated compounds 6a-e . Compounds 6b,d were ring-opened by hydrochloric acid in ethanol to yield trans-2-(1-carbethoxyethoxy)-1-acylaminomethylcyclohexane derivatives 7b,d . The 1H- and 13C-nmr investigation and X-ray analysis of 5b and 6c,d proved that the expected N-acylated derivatives were formed and that both rings of the trans anellated compounds have a chair conformation. |
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