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Some synthetic approaches to ropinirole (sk&f 101468-a): A potent dopamine receptor agonist |
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| Authors: | J. D. Hayler S. L. B. Howie R. G. Giles A. Negus P. W. Oxley T. C. Walsgrove S. E. Walsh R. E. Dagger J. M. Fortunak A. Mastrocola |
| Abstract: | Three new routes to ropinirole (SK&F 101468-A, 1 ) are described each involving the preparation of 3-chlorooxindole intermediates of type 3 from β-nitrostyrenes as the pivotal step. The superiority of sulphonate esters 17a-c as direct precursors to 1 over the bromide 11 is also described. |
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