On the metalation of 4-substituted pyridazines |
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| Authors: | Alain Turck,Nelly Pl ,Ljubica Mojovic,Bruno Ndzi,Guy Qu guiner,Norbert Haider,Herbert Schuller,Gottfried Heinisch |
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| Affiliation: | Alain Turck,Nelly Plé,Ljubica Mojovic,Bruno Ndzi,Guy Quéguiner,Norbert Haider,Herbert Schuller,Gottfried Heinisch |
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| Abstract: | A series of new pyridazines bearing ortho-directing groups at C-4 (protected/activated amino or carboxylic acid functionalities) was prepared and their metalation with lithium 2,2,6,6-tetramethylpiperidide was studied. Reactions of the ortho-lithiated species thus obtained with aldehydes as electrophiles opens an access to 4,5-disubstituted pyridazines 3, 4, 14 , and 15 . |
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