Palladium(0)-catalyzed allylation of 4(5)-substituted imidazoles, 5(6)-substituted benzimidazoles,benzotriazole and 5(6)-methylbenzotriazole |
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| Authors: | N Arnau Y Arredondo M Moreno-Maas R Pleixats M Villarroya |
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| Institution: | N. Arnau,Y. Arredondo,M. Moreno-Mañas,R. Pleixats,M. Villarroya |
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| Abstract: | Pd(0)-Catalyzed allylations of 4(5)-nitroimidazole, 1 , 2-methyl-4(5)-nitroimidazole, 2 , 4(5)-bromo-imidazole, 7 , 4(5)-methoxyimidazole, 10 , 5(6)-nitrobenzimidazole, 16a , 5(6)-methylbenzimidazole, 16b , benzotriazole, 19 , and 5(6)-methylbenzotriazole, 22 , were studied under several reaction conditions. Nitroimidazoles 1 and 2 were regioselectively allylated under thermodynamic control, leading to 1-allyl-4-nitro derivatives. |
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