Studies on the synthesis of some styryl-3-cyano-2(1H)-pyridinethiones and polyfunctionally substituted 3-aminothieno[2,3-b]-pyridine derivatives

The 3-cyano-4,6-dimethyl-2(1H)-pyridinethione was condensed with benzaldehyde in basic solution leads to styryl-3-cyano-2(1H)-pyridinethiones. Treatment of cinnamicaldehyde with cyanothioacetamide to give cinnamylidencyanothioacetamide, which can be cyclized with the appropriate ketones to afford the 3-cyano-5,6-polymethylene-4-styryl-2(1H)-pyridinethione derivatives. The polyfunctionally substituted 3-aminothieno2,3-b]pyridine derivatives were obtained in good yield by cyclization of 3-cyano-2(1H)-pyridinethione derivatives with appropriate α-halogeno carbonyl compounds and nitrile, respectively.