The Supramolecular Self-Assembly of Aminoglycoside Antibiotics and their Applications |
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Authors: | Ratan W Jadhav Dr Mohammad Al Kobaisi Dr Lathe A Jones Prof Ajayan Vinu Prof Sheshanath V Bhosale |
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Institution: | 1. School of Chemical Sciences, Goa University Taleigao Plateau, Goa, 403 206 INDIA;2. School of Science, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Australia;3. CAMIC, School of Science, RMIT University, GPO Box, 2476 Melbourne, VIC-3001, Australia;4. Global Innovative Center for Advanced Nanomaterials (GICAN), The University of Newcastle (UON), University Drive, Callaghan, Callaghan, NSW 2308 Australia |
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Abstract: | Aminoglycosides, a class of antibiotics that includes gentamicin, kanamycin, neomycin, streptomycin, tobramycin and apramycin, are derived from various streptomyces species. Despite the significant increase in the antibacterial resistant pathogens, aminoglycosides remain an important class of antimicrobial drugs due to their unique chemical structure which offers a broad spectrum of activity. The modification of antibiotics and their subsequent use in supramolecular chemistry is rarely reported. Given the importance of aminoglycosides, here we give a brief overview on the modification of 4,5- and 4,6-disubstituted deoxystreptamine classes of aminoglycosides through supramolecular chemistry and their potential for real world applications. We also make the case that the work in this area is gaining momentum, and there are significant opportunities to meet the challenges of modern antibiotics through the modification of aminoglycosides by harnessing the advantages of supramolecular chemistry. |
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Keywords: | supramolecular self-assemblies aminoglycosides antibiotics DNA superstructures |
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