STUDIES ON THE COMPETITION FOR CADMIUM ION BETWEEN CHELATING AGENTS AND BOVINE SERUM ALBUMIN |
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| Authors: | Li Rongchang Chen Baowei Wang Kui Wu Yonghui Wang Xiangyun |
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| Institution: | 1. Institute of Pharmaceutics and Pharmacology, Beijing Medical University;
2. Department of Technical Physics, Peking University |
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| Abstract: | Eleven chelating agents were studied for their capabilities to mobilize the cadmium bound tp bovine serum albumin(BSA).The parameter F,which is defined as the ratio between the percentages of cadmium bound to BSAin the presence and absence of chelating agents,can be used as the criterion to evaluate the mobilizing capability of chelating agent.The Fvalues determined experimentally lead to a mobilizing capability order:DTPA>EDTA>EGTA>NTA>TR1EN>PEN>CYS>HIS>SAThe polyaminopolycarboxylate type chelators mobilize cadmium effectively.Alinear relationship was found between1gFand lg k'CdL (conditional stability constant of the cadmium chelate). |
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