Synthesis and Antimicrobial Activity of Some New 4H-Pyrrolo[1,2-a]benzimidazoles |
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Authors: | JIANG Yuliang HAN Qiaorong SHEN Ronghua ZANG Xinxin WANG Bingxiang |
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Institution: | Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, P. R. China |
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Abstract: | Some new 4H-pyrrolo1,2-a]benzimidazoles(2a-2f) have been synthesized. The structures of these compounds were confirmed by IR, 1H NMR, mass spectroscopy and elemental analysis. Compound 2a was further confirmed by X-ray diffraction. The in vitro antimicrobial activities of these compounds were determined against some gram-positive bacteria, gram-negative bacteria and fungi and their drug-resistant isolates in comparison with standard drugs. Antimicrobial results indicate that compounds 2c, 2d and 2e show moderately active antibacterial properties, their minimum inhibitory concentrations are from 12.5 μg/mL to 125 μg/mL. In the series, the most active compound against C. albicans is compound 2f with an MIC value of 31.25 μg/mL. |
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Keywords: | 4H-Pyrrolo[1 2-a]benzimidazole Anti-bacterial Anti-fungal |
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