| Stereoselective Synthesis of （R）-Salmeterol via Asymmetric Cyanohydrin Reaction |
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| 引用本文： | LI Wei HUANG Hai JIN Xiaodong LIU Yujian XU Chaohang ZHU Hongjun. Stereoselective Synthesis of （R）-Salmeterol via Asymmetric Cyanohydrin Reaction[J]. 高等学校化学研究, 2014, 30(5): 770-773. DOI: 10.1007/s40242-014-4073-3 |
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| 作者姓名： | LI Wei HUANG Hai JIN Xiaodong LIU Yujian XU Chaohang ZHU Hongjun |
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| 作者单位： | Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China |
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| 基金项目： | Supported by the National Key Technology R＆D Program of China（No.2011BAE06A07-04）. |
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| 摘 要： | The authors described a short and highly enantioselective route to （R）-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-（4-phenylbutoxy） hexyl methanesulfonate.
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| 关 键 词： | 不对称合成 立体选择性合成 氰醇 醇反应 对映体选择性 亲核取代 磺酸酯 丁氧基 |
| 收稿时间： | 2014-03-06 |
Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction |
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| LI Wei,HUANG Hai,JIN Xiaodong,LIU Yujian,XU Chaohang,ZHU Hongjun. Stereoselective Synthesis of (R)-Salmeterol via Asymmetric Cyanohydrin Reaction[J]. Chemical Research in Chinese University, 2014, 30(5): 770-773. DOI: 10.1007/s40242-014-4073-3 |
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| Authors: | LI Wei HUANG Hai JIN Xiaodong LIU Yujian XU Chaohang ZHU Hongjun |
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| Affiliation: | Department of Applied Chemistry, College of Sciences, Nanjing Tech University, Nanjing 211816, P. R. China |
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| Abstract: | The authors described a short and highly enantioselective route to (R)-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-(4-phenylbutoxy) hexyl methanesulfonate. |
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| Keywords: | Asymmetric synthesis Catalysis Cyanohydrin Ethanolamine Methanesulfonate |
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