Identification of protease substrates by combinatorial profiling on TentaGel beads |
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| Authors: | Kofoed Jacob Reymond Jean-Louis |
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| Institution: | Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland. |
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| Abstract: | Reacting a 65,536 member combinatorial library of octapeptides on TentaGel beads with various proteases followed by selective staining of the free amino termini at the reacted bead surface and sequence determination by amino acid analysis allowed the rapid identification of protease substrates. |
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