| 环糊精超分子组装体与核酸的相互作用 |
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| 引用本文： | 陈湧,刘育.环糊精超分子组装体与核酸的相互作用[J].有机化学,2012,32(5):805-814. |
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| 作者姓名： | 陈湧 刘育 |
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| 作者单位： | 南开大学化学系 元素有机化学国家重点实验室 天津300071 |
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| 基金项目： | 973重大研究计划(No.2011CB932500);国家自然科学基金(Nos.20932004,91027007)资助项目~~ |
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| 摘 要： | 环糊精是一类由6～8个D-型葡萄糖连接而成的环聚多糖分子,目前已广泛应用于化学和生物学的许多领域.综述了一些生物活性的环糊精超分子组装体,如环糊精假聚轮烷、环糊精/金纳米粒子组装体、环糊精/富勒烯组装体、环糊精/碳纳米管组装体等的构筑及其与核酸的相互作用,如对核酸的切割、凝聚、传递作用和对核酸酶的抑制作用等方面的研究进展.
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| 关 键 词： | 环糊精 核酸 超分子组装体 |
Supramolecular Assembly of Cyclodextrins and Its Interactions with Nucleic Acid |
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| Chen, Yong
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Liu, Yu.Supramolecular Assembly of Cyclodextrins and Its Interactions with Nucleic Acid[J].Chinese Journal of Organic Chemistry,2012,32(5):805-814. |
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| Authors: | Chen Yong Liu Yu |
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| Institution: | Chen,Yong Liu,Yu*(State Key Laboratory of Elemento-Organic Chemistry,Department of Chemistry,Nankai University,Tianjin 300071) |
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| Abstract: | Cyclodextrins(CDs) are a class of cyclic oligosaccharides with six to eight D-glucose units and widely applied in many fields of chemistry and biology.This review deals with the representative contributions in the construction of some bioactive cyclodextrin-based supramolecular assemblies,including cyclodextrin polypseudorotaxane,cyclodextrin/gold nanoparticle assembly,cyclodextrin/fullerene assembly,cyclodextrin/carbon nanotube assembly,and their interactions with nucleic acids,including the nucleic acid cleavage,condensation,delivery and the inhibition of nucleic acid enzymes. |
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| Keywords: | cyclodextrin nucleic acid supramolecular assembly |
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