Pivaloylpyruvic acid as a new acylating reagent for amines |
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| Authors: | V. O. Koz'minykh N. M. Igidov E. S. Berezina E. N. Koz'minykh Yu. S. Kasatkina |
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| Affiliation: | 1. Perm State Pharmaceutical Academy, P.O. Box 8519, 614051, Perm, Russian Federation
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| Abstract: | Pivaloylpyruvic acid is an efficient reagent for preparative acylation of amines. A method for the synthesis of substituted pivaloylpyruvamides with domination of (Z)-β-keto-enol tautomer is proposed. The structure of pivaloylpyruvic acid and its amides, as well as the specific features of the reaction of pivaloylpyruvic acid with amines, are discussed. |
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