Cyclodextrin-conjugated nanocarrier for magnetically guided delivery of hydrophobic drugs |
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Authors: | Shashwat S Banerjee Dong-Hwang Chen |
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Institution: | (1) Department of Chemical Engineering, National Cheng Kung University, Tainan, 701, Taiwan, ROC; |
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Abstract: | A magnetic nanosystem that simultaneously implements the cyclodextrin–drug complexation power, bioadhesive property of gum
arabic (GA) and inherent magnetic properties of Fe3O4 nanoparticles, has recently been reported. In this study, a magnetic nanocarrier was fabricated by conjugating 2-hydroxypropyl-cyclodextrin
(HCD) onto the gum arabic modified magnetic nanoparticles (GAMNP). The analyses of transmission electron microscopy (TEM)
and dynamic light scattering (DLS) revealed that the product had a mean diameter of 14.8 nm and a mean hydrodynamic diameter
of 29.3 nm. This nanocarrier showed good loading efficiency for ketoprofen. In addition, the in vitro release profile of ketoprofen
from HCD-GAMNP was characterized by an initial fast release followed by a delayed release phase. In view of the better biocompatibility
and the combined properties like specific targeting, complexation ability with hydrophobic drugs makes the nanosystem an exciting
prospect for drug delivery. |
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Keywords: | |
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