Efficient synthesis of chromenopyridine and chromene via MCRs |
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| Authors: | Hai-Feng Gan, Wei-Wei Cao, Zheng Fang, Xin Li, Shi-Gui Tang, Kai Guo |
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| Affiliation: | a College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;b School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China |
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| Abstract: | MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions from different salicylaldehydes, malononitrile and different thiols (mol ratio = 1:2:1) were established. Mechanistic investigation suggests that the MCRs undergo different pathways at different temperatures and catalyzed by different organic bases. The structure of chromenopyridine and chromene are confirmed by crystal X-ray crystallography. |
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| Keywords: | Multi-component reaction Chromenopyridine Chromene Mechanistic study Reaction condition |
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