| One-pot synthesis of novel pyrido[2,3-d]pyrimidines using HAp-encapsulated-γ-Fe2O3 supported sulfonic acid nanocatalyst under solvent-free conditions |
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| 作者姓名： | Moona Mohsenimehr Manouchehr Mamaghani Farhad Shirini Mehdi Sheykhan Fatemeh Azimian Moghaddam |
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| 作者单位： | a Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran;
b Department of Chemistry, Islamic Azad University, Rasht Branch, Iran |
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| 基金项目： | the Research Council of University of Guilan for the financial support of this research work |
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| 摘 要： | Novel pyrido2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-γ-Fe2O3γ-Fe2O3@HAp-SO3H]catalyzed condensation of 6-arnino-2-（methylthio or ethylthio）pyrimidin-4（3H）-one,Meldrum＇s acid and aryl aldehydes at 60 ℃ and under solvent-free conditions.In this protocol the use of nanocatalyst provided a green,useful and rapid method to generate the products in short reaction times and excellent yields（88%-94%）.
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| 关 键 词： | 纳米催化剂 嘧啶衍生物 羟基磷灰石 无溶剂条件 一锅合成 Fe2O3 吡啶 包封 |
| 收稿时间： | 21 February 2014 |
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