Trimethylsilyldiazomethane (TMSD) as a new derivatization reagent for trace analysis of selected non-steroidal anti-inflammatory drugs (NSAIDs) by gas chromatography methods |
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Authors: | Natalia Migowska Piotr Stepnowski Monika Paszkiewicz Marek Gołębiowski Jolanta Kumirska |
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Institution: | (1) Department of Environmental Analysis, Faculty of Chemistry, University of Gdańsk, Sobieskiego 18/19, 80-952 Gdańsk, Poland; |
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Abstract: | Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common groups of pharmaceuticals detected in environmental
matrices. Although several derivatization procedures have been employed in the gas chromatographic analysis of NSAIDs, the
application of trimethylsilyldiazomethane has never yet been reported. This work has studied the derivatization of widely
used NSAIDs (ibuprofen, ketoprofen and naproxen) by trimethylsilyldiazomethane. Special emphasis was placed on the influence
of temperature and reaction time on the reaction yield, and on the determination of the instrumental detection limit. The
results are compared with those obtained by methylation using boron trifluoride methanol solution, and by silylation with
a mixture of N,O-bis(trimethylsilyl)trifluoroacetamide and trimethylchlorosilane (99:1, v/v) and with N-methyl-N-tert-butyldimethylsilyl]trifluoroacetamide. The derivatization of ibuprofen, ketoprofen and naproxen by trimethylsilyldiazomethane
was shown to be simple, fast, efficient, and suitable for trace analysis (the respective instrumental detection limits for
ibuprofen naproxen, and ketoprofen were 2, 4, and 4 ng). Trimethylsilyldiazomethane can be used as an alternative reagent
for determining acidic drugs in environmental matrices. |
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