Tandem hetero diels-alder reaction: synthesis of oxygenated macrocycles |
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| Authors: | Bear B R Shea K J |
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| Institution: | Department of Chemistry, 516 Rowland Hall, University of California, Irvine, Irvine, California 92697-2025, USA. |
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| Abstract: | structure: see text]. C2-symmetric, oxygenated macrocycles have been synthesized from simple acyclic precursors in a single step by a tandem hetero Diels-Alder reaction. Thermolysis and Lewis acid catalysis can effect this novel transformation. The tandem reaction product is formed in preference to the intramolecular cycloaddition product, and an explanation for this result is proposed. |
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