An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine |
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| Authors: | Liras S Davoren J E Bordner J |
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| Institution: | Pfizer Global Research and Development, Groton, Connecticut 06340, USA. spiros_liras@groton.pfizer.com |
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| Abstract: | structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction. |
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