首页 | 本学科首页   官方微博 | 高级检索  
     


In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals
Authors:Huh Yong-Min  Jun Young-wook  Song Ho-Taek  Kim Sungjun  Choi Jin-sil  Lee Jae-Hyun  Yoon Sarah  Kim Kyung-sup  Shin Jeon-Soo  Suh Jin-Suck  Cheon Jinwoo
Affiliation:Yonsei Nano-Medical Core Research Center, Department of Radiology, Yonsei University, Seoul 120-752, Korea.
Abstract:The unique properties of magnetic nanocrystals provide them with high potential as key probes and vectors in the next generation of biomedical applications. Although superparamagnetic iron oxide nanocrystals have been extensively studied as excellent magnetic resonance imaging (MRI) probes for various cell trafficking, gene expression, and cancer diagnosis, further development of in vivo MRI applications has been very limited. Here, we describe in vivo diagnosis of cancer, utilizing a well-defined magnetic nanocrystal probe system with multiple capabilities, such as small size, strong magnetism, high biocompatibility, and the possession of active functionality for desired receptors. Our magnetic nanocrystals are conjugated to a cancer-targeting antibody, Herceptin, and subsequent utilization of these conjugates as MRI probes has been successfully demonstrated for the monitoring of in vivo selective targeting events of human cancer cells implanted in live mice. Further conjugation of these nanocrystal probes with fluorescent dye-labeled antibodies enables both in vitro and ex vivo optical detection of cancer as well as in vivo MRI, which are potentially applicable for an advanced multimodal detection system. Our study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号