| A facile stereospecific synthesis of （Z）-2-sulfonyl-substituted 1,3-enynes via Sonogashira coupling of （E）-α-iodovinyl sulfones with 1-alkynes |
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| 作者姓名： | Wen Yan Hao Jian Wen Jiang Ming Zhong Cai |
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| 作者单位： | Wen Yan Hao，Jian Wen Jiang，Ming Zhong Cai * Department of Chemistry，Jiangxi Normal University，Nanchang 330022，China |
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| 基金项目： | Acknowledgments We thank the National Natural Science Foundation of China （No. 20462002） and Natural Science Foundation of Jiangxi Province （No. 0420015） for financial support. |
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| 摘 要： | (E)-a-Iodovinyl sulfones 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol% of Pd(PPh3)4 and 10 mol% of CuI to stereospecifically afford the corresponding (Z)-2- sulfonyl-substituted 1,3-enynes 3 in high yields.
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| 关 键 词： | 立体选择合成 2-硫磺取代1 3-烯炔 碘乙烯基砜 1-炔 |
| 收稿时间： | 1 March 2007 |
| 修稿时间： | 2007-03-01 |
A facile stereospecific synthesis of (Z)-2-sulfonyl-substituted 1,3-enynes via Sonogashira coupling of (E)-α-iodovinyl sulfones with 1-alkynes |
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| Wen Yan Hao Jian Wen Jiang Ming Zhong Cai.A facile stereospecific synthesis of (Z)-2-sulfonyl-substituted 1,3-enynes via Sonogashira coupling of (E)-α-iodovinyl sulfones with 1-alkynes[J].Chinese Chemical Letters,2007,18(7):773-776. |
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| Authors: | Wen Yan Hao Jian Wen Jiang Ming Zhong Cai |
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| Institution: | Department of Chemistry, Jiangxi Normal University, Nanchang 330022, China |
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| Abstract: | (E)-a-Iodovinyl sulfones 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol% of Pd(PPh3)4 and 10 mol% of CuI to stereospecifically afford the corresponding (Z)-2- sulfonyl-substituted 1,3-enynes 3 in high yields. |
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| Keywords: | (E)-a-Iodovinyl sulfone 1 3-Enynylsulfone Sonogashira coupling Terminal alkyne |
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