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One-pot catalytic asymmetric cascade synthesis of cycloheptane derivatives |
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| Authors: | Vesely Jan Rios Ramon Ibrahem Ismail Zhao Gui-Ling Eriksson Lars Córdova Armando |
| Institution: | Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm (Sweden). |
| Abstract: | A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiral-amine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (>25:1 d.r. and 98- >99 ee). |
| Keywords: | asymmetric catalysis cascade reaction chiral amines cycloaddition cycloheptane derivatives |
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