Efficacy of Low‐Dose Ultraviolet A‐1 Phototherapy for Parapsoriasis/Early‐Stage Mycosis Fungoides |
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| Authors: | Kenan Aydogan Serkan Yazici Saduman Balaban Adim Ferah Budak Hayriye Saricaoglu Sukran Tunali Emel Bulbul Baskan |
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| Institution: | 1. Department of Dermatology and Venereology, Uludag University School of Medicine, , Bursa, Turkey;2. Department of Pathology, Uludag University School of Medicine, , Bursa, Turkey;3. Department of Microbiology and Infectious Diseases, Uludag University School of Medicine, Immunology Unit, , Bursa, Turkey |
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| Abstract: | Mycosis fungoides (MF) and parapsoriasis (PP) are major dermatologic conditions for which phototherapy continues to be a successful and valuable treatment option. UVA‐1 phototherapy is effective in the management of cutaneous T‐cell mediated diseases. The aim of the study was to evaluate the efficacy and safety of low‐dose UVA‐1 phototherapy for the management of PP/early‐stage MF. A total of 30 patients, diagnosed with MF (n:19) or PP (n:11) were enrolled to the study. All patients were managed with low‐dose UVA‐1 (20 or 30 J cm?2). Response was assessed clinically and immunohistochemically. UVA‐1 treatment led to clinical and histological complete remission (CR) in 11 of 19 MF patients (57.9%), partial remission (PR) in three of 19 (15.8%), after a mean cumulative dose of 1665 (range, 860–3120) J cm?2 and mean number of 73 exposure (range, 43–107) sessions. Five patients with PP (45.5%) showed CR, and PR was observed in six patients with PP (54.5%) after a mean cumulative dose of 1723 (range, 1060–3030) J cm?2 and mean number of 74 exposure (range, 53–101) sessions. We conclude that low‐dose UVA‐1 therapy seems to be an effective, safe, and well‐tolerated treatment option for patients with PP/early‐stage MF. |
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