|
|||||
|
|
Optical resolution via catalytic generation of chiral auxiliary |
|
| Authors: | Hiroki Kiyama Tsubasa Inokuma Yusuke Kuroda Yousuke Yamaoka Kiyosei Takasu Ken-ichi Yamada |
| Affiliation: | 1. Graduate School of Pharmaceutical Sciences, Tokushima University, Shomachi, Tokushima 770-8505, Japan;2. Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan |
| Abstract: | A new catalytic method for separating enantiomers of racemic compounds is proposed. Catalytic asymmetric addition of racemic trans-2-substituted cyclohexanols to imines provided diastereomeric mixtures of aminals, and the subsequent separation of the enantiomers by silica-gel column chromatography and the hydrolysis of the aminals produced the alcohols in an optically active form. |
| Keywords: | Optical resolution Chiral alcohols Chiral magnesium phosphate Asymmetric addition Imines |
| 本文献已被 ScienceDirect 等数据库收录！ | |