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Concise asymmetric total synthesis of lycopodine and flabelliformine via cascade cyclization reaction |
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| Authors: | Kentaro Wada Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama |
| Affiliation: | Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan |
| Abstract: | The shortest asymmetric total synthesis of lycopodine (3) and the first asymmetric total synthesis of flabelliformine (4) were accomplished by a strategy that features a cascade cyclization of linear substrate (5) to construct tetracyclic structure (6). |
| Keywords: | Lycopodium alkaloid Lycopodine Flabelliformine Asymmetric total synthesis Cascade reaction |
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