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1,3-Dipolar cycloaddition of vinyloxy quinolines with α-alkoxy carbonyl aldonitrones or cyclic surrogates: A comparative study for an asymmetric access to trans 4-quinolinoxy oxaprolines |
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| Authors: | Abdelrahman Hamdi Mathieu Y Laurent Annie Hémon-Ribaud Amany S Mostafa Mohammed AM Massoud Khalid B Selim Gilles Dujardin |
| Institution: | 1. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt;2. Le Mans Université, IMMM-UMR 6283 CNRS, MSO Team, Faculté des Sciences, 72085, Le Mans, Cedex 9, France |
| Abstract: | The asymmetric access to unreported trans 4-quinolinoxy oxaproline precursors is investigated here in a comparative way by 1,3-dipolar cycloaddition of vinyloxy quinolines with chiral α-alkoxycarbonyl aldonitrones and chiral cyclic surrogates. |
| Keywords: | 1 3-Dipolar cycloaddition Nitrone Vinyloxy quinoline Isoxazolidine Oxaproline |
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