I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process |
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| Authors: | Liangzhen Hu Muhammad Ijaz Hussain Qingfu Deng Qing Liu Yangyang Feng Xiaohui Zhang Yan Xiong |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China;2. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | One-step base promoted strategy for cyanation of α,α-diaryl alcohols has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, respectively, up to 99% yield. Moreover, various azides and ethers could also be accessed from their respective nucleophiles under standard reaction conditions. |
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| Keywords: | Cyanation Diarylalcohols Dual activity |
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