Trace analysis of parabens,triclosan and related chlorophenols in water by headspace solid-phase microextraction with in situ derivatization and gas chromatography–tandem mass spectrometry |
| |
Authors: | Jorge Regueiro Elias Becerril Carmen Garcia-Jares Maria Llompart |
| |
Affiliation: | 1. Departamento de Quimica Analitica, Nutricion y Bromatologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain;2. Universidad Nacional Autonoma de Mexico, Instituto de Ingenieria, Ciudad Universitaria, 04510 Mexico, D.F., Mexico |
| |
Abstract: | An in situ derivatization solid-phase microextraction method has been developed for the determination of parabens, triclosan and related chlorophenols in water. Acetylated derivatives are selectively determined using gas chromatography with tandem mass spectrometry. Parameters affecting both derivatization and SPME procedures, such as fiber coating, extraction mode, temperature, volume of derivatizating reagent and ionic strength, are studied and optimized through a multifactorial experimental design. The performance of the method is studied in terms of accuracy, linearity, precision and limits of detection. Quantitative recoveries (≥82%) and satisfactory precision (RSD ≤ 12%) are obtained. Limits of detection at the low picogram per millilitre level are achieved for all target compounds. Linearity is studied in a wide range of concentrations and an analysis of variance with a lack-of-fit test is run to validate the calibration data. Extraction time profiles are also obtained. Finally, the applicability of the proposed method is demonstrated for several real samples including river water, wastewaters and swimming pool water. Since no matrix effects are observed, quantification can readily be carried out by external calibration with ultrapure water standards. |
| |
Keywords: | Parabens Triclosan Water analysis Solid-phase microextraction Microextraction Headspace analysis Derivatization Experimental design |
本文献已被 ScienceDirect 等数据库收录! |
|