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Semi-micro-monolithic columns using macroporous silica rods with improved performance |
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| Authors: | Kei Morisato Shota Miyazaki Masayoshi Ohira Masahiro Furuno Masahiko Nyudo Hiroyuki Terashima Kazuki Nakanishi |
| Institution: | 1. GL Sciences Inc./Kyoto University, 12, 14 Yoshida Kawaramachi, Sakyo-ku, Kyoto 606-8305, Japan;2. GL Sciences Inc., 237-2 Sayamagahara, Iruma, Saitama 358-0032, Japan;3. GL Sciences Inc., 5-3 Nagasone, Okajima, Fukushima 960-8201, Japan;4. Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan |
| Abstract: | Monolithic silica columns in semi-micro-format have been synthesized using poly(acrylic acid) as a phase-separation inducer via a sol–gel route. The absence of a thick skin layer accompanied by deformation of the micrometer-sized gelling skeletons on the outermost part of the macroporous silica rod contributed to improve the efficiency of monolithic silica columns as thick as 2.4 mm in diameter. The kinetic plot analysis revealed that monolithic silica columns with macropore diameter of 1 μm and skeleton thickness of 1 μm with decreased macroporosity behave similarly to columns packed with 3 μm particles with slightly lower back pressure. |
| Keywords: | Monolithic silica column Porosity Poly(acrylic acid) Kinetic plot |
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