Fundamental equation of the dual flow rate-solvent gradient elution in liquid chromatography |
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| Authors: | Kostas Papachristos Panos Nikitas |
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| Affiliation: | Laboratory of Physical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece |
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| Abstract: | An alternative expression of the fundamental equation of multi-mode gradient elution involving simultaneous changes in mobile phase composition and flow rate is derived using simple kinetic arguments and graphic interpretation. The new expression consists of a system of two integral equations and provides an easy and direct way of predicting retention times under dual-mode gradient conditions. |
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| Keywords: | Liquid chromatography Fundamental equation Dual-mode gradient elution Flow programming |
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