Acceleration of arylzinc formation and its enantioselective addition to aldehydes by microwave irradiation and aziridine-2-methanol catalysts |
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Authors: | Braga Antonio L Paixão Marcio W Westermann Bernhard Schneider Paulo H Wessjohann Ludger A |
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Affiliation: | Universidade Federal de Santa Maria, Departamento de Química, 97105-900, Santa Maria RS, Brazil. albraga@quimica.ufsm.br |
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Abstract: | The formation and 2-amino alcohol catalyzed addition of arylzinc reagents from and with boronic acids, respectively, is drastically accelerated to a few minutes under microwave irradiation without loss of enantioselectivity (up to 98% ee). Of the amino acid derived catalysts tested, the conformationally restricted bulky substituted aziridine-2-methanols derived from serine show the best overall performance in the formation of diarylmethanols. |
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