Chemical mechanism of controlled nitric oxide release from trans-[RuCl([15]aneN4)NO](PF6)2 as a vasorelaxant agent |
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| Authors: | Mario Sérgio Pereira Marchesi Simone Aparecida Cicillini Ana Carolina Lemos Prazias Lusiane M Bendhack Alzir Azevedo Batista Roberto Santana da Silva |
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| Institution: | 1. Faculdade de Ci??ncias Farmac??uticas de Ribeir?o Preto, Universidade de S?o Paulo, Av. Caf?? s/n, Ribeir?o Preto, S?o Paulo, CEP 14040-903, Brazil
2. Departamento de Qu??mica, Universidade Federal de S?o Carlos, CP 676, S?o Carlos, S?o Paulo, CEP 13565-905, Brazil
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| Abstract: | The nitrosyl ruthenium complex, trans-RuCl(15]aneN4)NO](PF6)2, (15]aneN4?=?1,4,8,12-tetraazacyclopentadecane), exhibits vasorelaxation characteristics attributed to its nitric oxide release properties. The observed in vitro and in vivo vasodilation is dependent on noradrenaline concentration. We report here the chemical mechanism of the reaction between noradrenaline and trans-RuCl(15]aneN4)NO](PF6)2 in aqueous phosphate buffer solution at pH 7.40. NO measurement by NO-sensor electrode, cyclic voltammetry, 31PNMR and HPLC analysis were used to investigate the reduction process as the fundamental step for NO release characteristic of trans-RuCl(15]aneN4)NO](PF6)2. A supramolecular species containing HPO4 2? as a bridging group between noradrenaline and trans-RuCl(15]aneN4)NO](PF6)2 is suggested as an intermediate prior to the reduction of the nitrosyl ruthenium complex. |
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