Abstract: | 5,6-Dihydro-8-methyl-4H-pyrazino3,2,1-j,k]carbazole was obtained by the reaction of -bromoacetaldehyde dibutylacetal, ammonium acetate, and 1,2,3,4-tetrahydro-6-methyl-1-ketocarbazole in acetic acid. The reduction of 5,6-dihydro-8-methyl-4H-pyrazino3,2,1-j,k]carbazole or its hydrochloride with sodium borohydride leads to 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino3,2,1-j,k]carbazole hydrochloride — the medicinal preparation pirazidol.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1362–1363, October, 1983. |