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New simple laboratory method for the synthesis of pirazidol
Authors:A N Grinev  É S Krichevskii  O B Romanova
Institution:(1) S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021 Moscow
Abstract:5,6-Dihydro-8-methyl-4H-pyrazino3,2,1-j,k]carbazole was obtained by the reaction of agr-bromoacetaldehyde dibutylacetal, ammonium acetate, and 1,2,3,4-tetrahydro-6-methyl-1-ketocarbazole in acetic acid. The reduction of 5,6-dihydro-8-methyl-4H-pyrazino3,2,1-j,k]carbazole or its hydrochloride with sodium borohydride leads to 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino3,2,1-j,k]carbazole hydrochloride — the medicinal preparation pirazidol.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1362–1363, October, 1983.
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