Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed kinetic resolution of epoxides |
| |
Authors: | Elenkov Maja Majerić Tang Lixia Meetsma Auke Hauer Bernhard Janssen Dick B |
| |
Affiliation: | Ruder Boskovi? Institute, Zagreb, Croatia. |
| |
Abstract: | Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69-98% ee). This is the first example of the biocatalytic conversion of a range of epoxides to the corresponding oxazolidinones. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |