| Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration |
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| 作者姓名： | 陈文亮 刘蓉 崔厚欣 徐可欣 吕丽娜 |
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| 作者单位： | State Key Laboratory of Precision Measuring Technology and Instruments，Tianjin University，Tianjin 300072，State Key Laboratory of Precision Measuring Technology and Instruments，Tianjin University，Tianjin 300072，State Key Laboratory of Precision Measuring Technology and Instruments，Tianjin University，Tianjin 300072，State Key Laboratory of Precision Measuring Technology and Instruments，Tianjin University，Tianjin 300072，State Key Laboratory of Precision Measuring Technology and Instruments，Tianjin University，Tianjin 300072 |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (No. 30170261)，the Natural Science Foundation of Tianjin (No. 023800411). |
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| 摘 要： | In this paper, the propagation characteristics of near-infrared (NIR) light in the palm tissue are analyzed, and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasive blood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectance spectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopy are designed. Based on this system, oral glucose tolerance tests are performed to measure the blood glucose concentrations of two young healthy volunteers. The partial least square calibration model is then constructed by all individual experimental data. The final result shows that correlation coefficients of the two experiments between the predicted blood glucose concentrations and the reference blood glucose concentrations are 0.9870 and 0.9854, respectively. The root mean square errors of prediction of full cross validation are 0.54 and 0.52 mmol/1, respectively.
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